Is Belly Fat Different Than Thigh Fat?

belly versus thigh fat

Oh yeah. It’s different. In fact, not all belly fat is the same, even in the same belly. But scientists are exploring the differences in belly versus thigh fat for a reason. They want to better understand not only what the differences are, but how to manipulate them.

Study of Genetic Differences

It’s been known for awhile that belly fat increases your risk for cardiovascular and metabolic diseases. This is the active fat that makes being an apple shape more concerning. The thigh fat that goes into making women hippy also makes them pear-shaped. Compared to the apple shape more typical of men, the pear shape is the better deal.

But researchers wanted to look into genetic differences in belly versus thigh fat. And not unexpectedly, the genetics were different. The belly fat was much more active than that in the thigh. Researchers also looked at stem cells from those regions and found that they were already placement specific. They already exhibited the markers correlating with the region of the body they were meant for.

Homeobox Genes

One kind of gene researchers looked at was homeobox genes. It’s these genes, they believe, that are responsible for programming the fat cells. And it’s that programming that determines how fat cells respond to chemical signals. (To some degree, they respond differently depending on their location – belly or thigh.)

And when they cultured stem cells in the lab, the genes still showed placement-specific attributes. It’s important because it means the differences between belly fat and thigh fat can’t be caused by environmental factors. The stem cells weren’t exposed to any. So the differences must be genetic.


The goal, of course, is to find a way to make belly fat less damaging. One possibility researchers are looking at is redistributing belly fat. And this is the first step.

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